Journal Club

Journal Club is a resident driven initiative designed to improve residents' abilities to critically appraise articles and improve their understanding of study design and statistical analysis. Every other month residents meet during the evening to discuss two articles on a particular emergency medicine subject. This is a very interactive discussion with participation from residents of all years.

Journal Club 2016-2017


  • Kudenchuck PJ, et al. Amiodarone, lidocaine, or placebo in out-of-hospital cardiac arrest. N Engl J Med 2016;374:1711-22
  • Lee YH, et al. Refractory ventricular fibrillation treated with esmolol. Resuscitation 2016;107:150-5


  • Weekes AJ, et al. Diagnostic accuracy of right ventricular dysfunction markers in normotensive emergency department patients with acute pulmonary embolism. Ann Emerg Med 2016;68(3):277-91
  • Gaspari R, et al. Emergency department point-of-care ultrasound in out-of-hospital and in-ED cardiac arrest. Resuscitation 2016;109:33-39

Respirology & Ventilation

  • Reher MW, et al. A randomized controlled noninferiority trial of single dose of oral dexamethasone versus five days of oral prednisone in acute adult asthma. Ann Emerg Med 2016;68(5):608-13
  • Girardis R, et al. Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the oxygen-ICU randomized clinical trial. JAMA 2016;316(15):1584-9


Past Journal Club Articles:



  • Ferrer R, Martin-Loeches I, Phillips G, et al. Emipiric antibiotic treatment reduces mortality in severe septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med 2014;42(8):1749-55.
  • Mouncey PR, Osborn TM, Power GS, et al. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med 2015;372:1301-11


  • Holcomb JB, et. al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA 2015; 313(5):471-82
  • Cooper DJ, et. al. Decompressive craniectomy in diffuse traumatic brain injury. N Engl J Med 2011; 364(16):1493-1502

Pre-Hospital Medicine

  • Sanghavi P, Jena AB, Newhouse JP, Zaslavsky AM. Outcome of basic versus advanced life support for out-of-hospital medical emergencies. Ann Intern Med 2015; 163(9):681-90
  • Nichol G, et. al. Trial of continuous or interrupted chest compressions during CPR. N Engl J Med 2015; 373(23)2203-14

​Lipid Emulsion Therapy

  • Varney SM, Bebarta VS, Boudreau SM, Bargas TE, Castaneda M, Zarzabal LA. Intravenous lipid emulsion therapy for severe dihenhydramine toxicity: A randomized, controlled pilot study in a swine model. Ann Emerg Med 2016; 67(2):196-205
  • Heinonen JA, Litnius E, Salmi T, Haasio J, Tarkkila P, Backma JT, Rosenberg PH. Intravenous lipid emulsion given to volunteers does not affect sympoms of lidocaine brain toxicity. Basic Clin Pharmacol 2015; 116:378-83

Mental Practice & Cognitive Bias in EM

  • Lorello GR, Hicks CM, Ahmed SA, Unger Z, Chandra D, Hayter MA. Mental practice: A simple tool to improve team based trauma resuscitation. CJEM 2016; 18(2):136-42
  • Croskerry P. From mindless to mindful practice: Cognitive bias and clinical decision making. N Engl J Med 2013; 368(26):2445-9
  • Moore CL, Bomann S, Daniels B, et al. Derivation and validation of a clinical prediction rule for uncomplicated ureteral stone--the STONE score: retrospective and prospective observational cohort studies. BMJ;348:g2191.
  • Smith-Bindman R, Aubin C, Bailitz J, et al. Ultrasonography versus computed tomography for suspected nephrolithiasis. N Engl J Med;371:1100-10.
Pre-Hospital Airway
  • Hasegawa K, Hiraide A, Chang Y, Brown DF. Association of prehospital advanced airway management with neurologic outcome and survival in patients with out-of-hospital cardiac arrest. JAMA;309:257-66.
  • Stiell IG, Wells GA, Field B, et al. Advanced cardiac life support in out-of-hospital cardiac arrest. N Engl J Med 2004;351:647-56.
Post-Arrest Hypothermia
  • Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002;346:549-56.
  • Nielsen N, Wetterslev J, Cronberg T, et al. Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest. N Engl J Med;369:2197-206.
  • Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368-77.
  • Yealy DM, Kellum JA, Huang DT, et al. A randomized trial of protocol-based care for early septic shock. N Engl J Med;370:1683-93.


  • Ezekowitz et al.  Rationale and design of RE-LY: Randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran.  American Heart Journal 157:805-510, 2009.
  • Connolly et al.  Dabigatran versus Warfarin in Patients with Atrial Fibrillation.  NEJM 361(12): 1139-51, 2009.
  • Shulman et al.  Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism.  NEJM 361(24): 2342-52, 2009.
  • Engstrom et al.  Prednisolone and Valaciclovir in Bell's Palsy:  a randomized, double blind, placebo controlled multicentre trial.  Lancet Neurology, 2008;7: 993-1000.
    Sullivan et al.  Early treatment with prednisolone or acyclovir in Bell's Palsy. NEJM 357; 16: 1598-1607.
  • Corneli et al.  A multicenter randomized controlled trial of dexamethasone for bronchioitis.  NEJM 357; 4: 332-9, July 26, 2007.
    Plint et al.  Epinephrine and dexamethasone in children with bronchiolitis.  NEJM 360; 20: 2079-89, May 14, 2009.


  • COMMIT Group. Addition of clopidogrel to aspirin in 45 852 patients with acute myocardial infarction. Lancet 366: 1688. Nov. 2005.
  • Sabatine et al. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST segment elevation. NEJM 352(12):1179. March 15, 2005.
  • Stiell et al The OPALS Major Trauma Study. CMAJ 2008; 178(9):1141-52Cooper et al. 
  • Prehospital Hypertonic Saline Resuscitation of Patients with Hypotension and Severe Traumatic Brain Injury. JAMA March 17, 2004; 291(11):1350-57.
  • Morley et al.  "Part 3:  Evidence Evaluation Process; 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations". Circulation. Volume 122 Issue 16 Supplement 2, October 18, 2010.
  • Morrison et al.  "Part 8:  Advanced Life Support; 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations". Circulation. Volume 122 Issue 16 Supplement 2, October 18, 2010.
  • HACA Study Group.  Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest. NEJM 346:8, 549-56; Feb 21 2002.
  • Bernard et al. Treatment of Comatose Survivors of Out of Hospital Cardiac Arrest with Induced Hypothermia.  NEJM 346:8, 557-563; Feb 21 2002.Verbeek PR et al.  Derivation of a termination-of-resuscitation guideline for emergency medical technicians using automated external defibrillators. Academic Emergency Medicine.  9(7):671-8, 2002 Jul.
  • Morrison et al.  Validation of a Rule for Termination of Resuscitation in Out of Hospital Cardiac Arrest.  NEJM 355:5  Aug. 2006
  • Morrison et al.  Validation of a universal prehospital termination of resuscitation clinical prediction rule for advanced and basic life support providers. Resuscitation.  80(3):324-8, 2009 Mar.Decker et al.  A Prospective Randomized Trial of an Emergency Department Observation Unit for Acute Onset Atrial Fibrillation.  Annals of Emergency Medicine 52(4):322; October 2008.
  • Stiell et al.  Association of the Ottawa Aggressive Protocol with Rapid Discharge of Emergency Department Patients with Recent-Onset Atrial Fibrillation or Flutter.  CJEM 12(3): 181; May 2010.


  • Reichlin T et al. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med 2009;361:858-67.
  • Keller T et al. Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med 2009;361:868-77.
  • Singh J et al. Incidence and predictors of critical events during urgent air medical transport. CMAJ 2009;181:580-4.
  • Garza A et al. Improved patient survival using a modified resuscitation protocol for out-of-hospital cardiac arrest.  Circulation 2009;119:2597-2605.
  • Bjornson C et al. A randomized trial of a single dose of oral dexamethasone for mild croup. N Engl J Med 2004;351:1306-13.
  • Corneli H et al. A multicenter, randomized, controlled trial of dexamethasone for bronchiolitis.N Engl J Med 2007;357:331­9.
  • Panickar J et al. Oral prednisolone for preschool children with acute virus-induced wheezing. N Engl J Med 2009;360:329-38.
  • Plint A et al. Epinephrine and bronchiolitis in children with bronchiolitis. N Engl J Med 2009;360:329-38.
  • Colman I et al. Parenteral dexamethasone for acute severe migraine headache: meta-analysis of randomised controlled trials for preventing recurrence. BMJ 2008;336:1359-1361.
  • Kely AM et al. The relative efficacy of phenothiazines for the treatment of acute migraine: a meta-analysis. Headache 2009;49:1324-1332.